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Advanced Digital Microscopy Core Facility, IRB Barcelona
c. Baldiri Reixac, 10-12. E-08028 Barcelona
tel: +34 93 40 34647, microscopy(at)irbbarcelona(dot)org
The Advanced Digital Microscopy is a Core Facility of the IRB Barcelona.
It was Inaugurated in January 2009 and offers 24/7 access and support to 13 state-of-the-art and conventional imaging instruments for Life Science research, from high content imaging in widefield, confocal and super resolution microscopy, to emerging techniques for cell manipulation and lightsheet-based 3D imaging.
Open Access in two Nodes of EUROBIOIMAGING-ERIC
Open Access in two Nodes of EUROBIOIMAGING-ERIC
Since 2023, ADM contributes to the European Research Infrastructure for Bioimaging, within two nodes:
Access to Advanced Light Microscopy
ADM supports on average >200 users per year from IRB Barcelona and external entities, i.e. public Institutions in Barcelona/Spain/Europe and other private companies. In brief, ADM offers 24/7 access to laser scanning spectral and hyperspectral imaging, spinning disk confocal microscopy, fully automated widefield and confocal screening, TIRF, laser manipulation (FRAP, laser nanosurgery, photoactivation), fluorescence macroscopy and stereoscopy, micromanipulation and microinjection, Lightsheet fluorescence Microscopy (SPIM) from macro- and micro- resolution, Fluorescence Lifetime Imaging (FLIM) and Time-correlated Single Photon Counting (TCSPC) confocal Microscopy (including derivatives e.g. FCS, FCCS, FLCS etc...), and Super Resolution Imaging (STED, PALM/STORM, SIM, ISM with Airyscan, Expansion Microscopy).
Services
ADM assists scientists throughout the full process of microscopy experiments: project design, training in the use of bioimaging technology, induction to autonomous use of instruments, processing data and analyzing/visualizing images, assist scientists in interpreting and shaping final results.
ADM staff is responsible for the maintenance of the instruments, in close collaboration with industry partners, to provide non-stop services, 24/7.
Methods & Technology Development
We also develop and give access to highly specialized instruments, which are either not commercially available or perform beyond standards of existing commercial systems, e.g. laser nanosurgery for living cells and organisms, Lightsheet Fluorescence Microscopy both for living organisms (SPIM) or for large samples (MacroSPIM, e.g. optically cleared organs, tumors).
Highlights:
- ADM offers a unique Lightsheet-based system dedicated to 3D-Imaging of full transparent organs and tumors.
- ADM develops ‘Intelligent Imaging’ for multiscale imaging and rare events detection.
- ADM hosts custom OPM: Oblique Plane Microscopy, for the deep and high-throughput imaging of living organoids.
Past collaborations with the following partners: Leica Microsystems, Cytoo, Izasa (Nikon distributors in Spain), Acquifer Gmbh (reference center).
Bioimage Analysis
ADM is very active in Image Processing and Analysis to address existing gaps in the panel of available open source and commercial software for Image processing. We focus on developing custom software tools tailored to the the specific needs of our scientists and to accelerate/improve the outcome of microscopy experiments. We also develop signal processing tools and data analysis routines to address the new challenges brought by the large amounts of data generated by high-throughput and 3D Imaging.
funded by the EU COST framework, COST Action CA15124 (2016-2021)
A New Network for BioImage Analysts: NEUBIAS
IRB Barcelona, together with other 14 institutions in Europe, has constituted a new network of BioImage Analysts through the award of a COST Action under the competitive call of 2015.
The Action started activities on May 3rd, 2016. IRB Barcelona acts as Grant Holder for the Action, which has established a series of activities for the development of BioImage Analyst professionals in Europe, for a period of 4 years.: 15 Training schools in 4 years for over 400 trainees, 10 workshops, development of online tools and repositories, a program of 50 transnational staff exchanges, textbooks, etc...
ADM played a leading role in the establishment of the following resources:
biii.eu: The Bioimage Informatics Index, an crowd-sourced repository, aimed to exhaustively catalogue all tools and workflows for Bioimage Analysis.
BIAFLOWS: A repository to benchmark and reproducibly deploy Bioimage analaysis workflows.
NEUBIAS Academy: An intense series of 20 bleeding-edge live webinars by Bioimage Analysis experts, that accompanied the scientific community during the pandemics confinement in April-June 2020, with over 10.000 registrations in 9 weeks, and 21.000 views on our NEUBIAS Youtube channel.
NEUBIAS F1000R Gateway: Launched in March 2020, this new publication platform will collect advances in Bioimage Analysis: articles, posters, Slides, more...
In 2019, the Action counts with over 250 members in 43 countries in Europe and beyond (including Australia, USA, Singapore, Brazil). The action is extended until October 2020.
More information at www.neubias.org
Access to Technology, Networks
Access to Technology, Networks
EUROBIOIMAGING-ERIC
2024: ADM receives a Job Shadowing visitor from VIB (BE).
2023: Spain joins EUROBIOIMAGING-ERIC, IRB Barcelona now contributes in two nodes, together with other partners in Barcelona (ICFO, UB and CRG).
2019: Eurobioimaging is now Eurobioimaging-ERIC
ADM takes part in EuroBioImaging, a large‐scale pan‐European research infrastructure project on the European Strategy Forum on Research Infrastructures (ESFRI) Roadmap, aiming at constructing a network Infrastructure for Biomedical and Life Science Imaging.
ADM participates in 2 Nodes:
- B-MIN: Barcelona Mesoscopic Imaging Node, together with ICFO.
- B-LIVIN: Barcelona Live and Intravital Imaging Node, together with the University of Barcelona and the CRG.
In the 1st Open Call for Euro-BioImaging Nodes, more than 220 imaging facilities from 19 different European countries submitted 71 applications for expressing their interest to become part of Euro-BioImaging. The Interim Board has nominated 28 Nodes candidates in 2015, which included BMIN and BLIVIN.
REMOA
ADM is an active and founding member of the Spanish Network of Advanced Light Microscopy (REMOA: Red Española de Microscopia Óptica Avanzada), whose first founding meeting was hosted by IRB Barcelona in March 2011.
In 2016, REMOA joined efforts with its homologous network in Portugal PPBI, to convert the conference into SPAOM: Spanish and Portuguese Advanced Optical Microscopy meetings series. Check the latest news here.
Events
Events
PAST EVENTS co-organized by ADM:
2015
15th International ELMI Meeting in Sitges-Barcelona !
co-organized by IRB Barcelona, CRG, INT Meetings
in Barcelona, co-organized by IRB Barcelona, CRG and ICFO, INT Meetings
2014
1st int. Lightsheet Fluorescence Microscopy Conference
2013
European BioImage Analysis Symposium
ADM Layout (2010)
Layout Legend:
1: SP5 confocal + multiphoton,
2: Automated widefield for High-content Imaging + TIRF,
3: SPE confocal,
4: LSM780 + FLIM, 5: Fluorescence Macroscope,
6: Stereoscope,
7: Confocal spinning disk, 9/10: LSM880 confocal + Fast Airyscan, Elyra PS1 SIM+PALM
11: Office space
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